For mediastinal lymphoma, COP (cyclophosphamide, vincristine, prednisolone) is the best-supported first-line protocol, with an overall response rate of 94.7–96.74% and median survival times of 338–484 days. For alimentary intermediate- to large-cell lymphoma, CHOP (cyclophosphamide, doxorubicin, vincristine, prednisolone) and its mitoxantrone-substituted equivalent CMOP (cyclophosphamide, mitoxantrone, vincristine, prednisolone) are the standard of care, with response rates of 66% and median survival times of 80–103 days — substantially shorter than mediastinal disease.Journal of Vete…+3

Mediastinal lymphoma responds exceptionally well to COP. Complete response rates reach 61.5–81.52% and partial response rates 15.22–34.0%, with an overall response rate of 94.7–96.74%.Journal of Feli…+1 Median survival with COP is 484 days in FeLV-negative UK cats and 338 days in FeLV-positive cats.Journal of Feli…+1 The Madison-Wisconsin (CHOP-based) protocol produces a statistically equivalent median survival of 211 days for mediastinal disease, with no significant difference in response rate (67% vs. 62% for COP).Journal of Feli… Cats achieving complete remission survive substantially longer than those with partial remission: 980 days versus 42 days.Journal of Feli… Young age (under 4 years) is a positive prognostic factor in FeLV-positive mediastinal cases.Animals

Alimentary intermediate- to large-cell lymphoma carries a worse prognosis regardless of protocol. CHOP and CMOP produce identical response rates of 66%, with median progression-free intervals of 59 days (CHOP) and 69 days (CMOP) and median survival times of 80 days (CHOP) and 103 days (CMOP) — differences that are not statistically significant.Journal of Feli… CMOP is a suitable substitute for CHOP: it can be administered as an intravenous bolus and carries less risk of catastrophic extravasation injury compared with doxorubicin.Journal of Feli… For cats achieving complete remission on CMOP, median survival extends to 1,176 days.Journal of Feli…

The VAPC protocol (prednisolone, L-asparaginase, doxorubicin, vinblastine, higher-dose cyclophosphamide, and oral procarbazine) achieves a complete response rate of 68.4% in alimentary intermediate- to high-grade lymphoma, with a median survival of 341 days in complete responders and a median progression-free survival of 184 days across all cats.Veterinary and… One-year, two-year, and three-year survival rates are 35.4%, 26.5%, and 26.5%, respectively.Veterinary and… A lymphocyte-to-monocyte ratio greater than 3.4 predicts a median progression-free survival of 700 days versus 126 days at or below 3.4, and B-cell phenotype predicts 220 days versus 42 days for T-cell phenotype.Veterinary and…

For high-grade and large granular lymphocyte alimentary lymphoma specifically, outcomes with COP- or CHOP-based protocols are poor. Overall response rate is 42% (complete response 20%, partial response 22%, stable disease 36%, progressive disease 22%), with a median progression-free interval of 148 days and median overall survival of 131 days.Veterinary and… Diffuse gastrointestinal infiltration and involvement of non-haematopoietic organs are negative prognostic factors; absence of lymph node involvement and receipt of rescue treatment are positive prognostic factors.Veterinary and…

Colorectal intermediate- to large-cell lymphoma is a distinct subset where surgical resection offers a relatively favorable outcome compared with the same histological grade elsewhere in the gastrointestinal tract.Journal of Feli…

Would you like to review rescue protocol options for cats that relapse or fail to achieve complete remission on first-line therapy?