The isoxazoline class (fluralaner, sarolaner, lotilaner, afoxolaner) delivers the highest and most consistent flea and tick efficacy in dogs, with mean reductions exceeding 97% sustained across full label intervals. The imidacloprid/flumethrin collar (Seresto) provides comparable long-term control over 7–8 months, while topical fipronil-based products are effective but show greater variability, particularly against ticks.

Oral Isoxazolines

Fluralaner (Bravecto) oral chew achieves flea-control efficacy of 99.2%, 99.8%, 99.8%, and 99.9% at weeks 2, 4, 8, and 12 from a single dose, compared to 94.1%, 93.0%, 96.0%, and 97.3% for topical fipronil over the same period.Parasites and V… Tick-control efficacy for fluralaner was 99.9%, 99.9%, 99.7%, and 100% at those same time points.Parasites and V… Of dogs with flea allergy dermatitis (FAD) at enrollment, 85.7% in the fluralaner group showed no clinical FAD signs through study completion, versus 55.6% in the fipronil group.Parasites and V…

Injectable fluralaner (Bravecto injectable, 15 mg/kg SC) provides year-long flea and tick control equivalent to 12 monthly afoxolaner doses. From visits 2 through 10, ≥95% of fluralaner-treated dogs were tick-free and ≥93% were flea-free; tick and flea counts were reduced by >99% from baseline.Parasites and V… Afoxolaner achieved >98% tick reduction and >97% flea reduction over the same period, with non-inferiority confirmed at all visits.Parasites and V… No unexpected adverse events occurred in either group, and no interactions with concomitantly administered vaccines or medications were observed.Parasites and V…

Topical fluralaner controls fleas for 12 weeks from a single application. Flea-count reductions at weeks 4, 8, and 12 met the ≥90% efficacy threshold required for the study endpoint.Parasites and V…

Sarolaner (Simparica, minimum 2.0 mg/kg PO q30d) achieves flea efficacy of 98.8%, 99.4%, >99.9%, and >99.9% on days 14, 30, 60, and 90, and tick efficacy of 97.4%, 97.6%, 99.8%, and 100% at those same time points.Veterinary Para… Sarolaner was superior to fipronil spot-on for tick control on day 30 and non-inferior at all other time points.Veterinary Para… All 42 FAD-affected dogs showed improvement in clinical signs by study end.Veterinary Para… No treatment-related adverse events were reported.Veterinary Para…

Sarolaner/moxidectin/pyrantel (Simparica Trio, 1.2–2.4 mg/kg sarolaner component PO q30d) maintains flea efficacy ≥97.9% and tick efficacy ≥94.8% through day 30, with the comparator afoxolaner/milbemycin oxime achieving ≥96.1% flea and ≥94.4% tick efficacy over the same period.Parasites and V… FAD clinical signs improved following treatment, and the tablet was voluntarily consumed on ≥78% of the 485 occasions offered.Parasites and V…

Lotilaner (Credelio, minimum 20 mg/kg PO q30d) reduces flea counts by 99.3%, 99.9%, and 100% on days 30, 60, and 90, with 100% of lotilaner-treated dogs flea-free on day 90 versus 93% of afoxolaner-treated dogs.Parasites and V… Both products alleviated FAD clinical signs in affected dogs, and palatability was high — 94% of lotilaner and 96% of afoxolaner treatments were accepted when offered.Parasites and V… For ticks, lotilaner achieves geometric mean count reductions of ≥98% from day 7 through day 56, reaching 100% efficacy on day 56, and maintains 100% of dogs tick-free on days 70 and 84.Parasites and V… Overall tick efficacy across all post-enrollment visits was 99.3% for lotilaner versus 98.3% for fipronil/(S)-methoprene.Parasites and V…

Imidacloprid/Flumethrin Collar (Seresto)

The imidacloprid 10%/flumethrin 4.5% collar (Seresto) reduces flea counts by 94.1–100% (overall mean 96.7%) and tick counts by 91.2–100% (overall mean 94.7%) in dogs over 8 months, with efficacy maintained at ≥90% for ticks and ≥95% for fleas throughout the full label period.Parasites and V… In a shelter field study, the collar provided overall efficacies of 99.7% against ticks and 100% against fleas, and reduced tick-borne pathogen transmission (Anaplasma platys and Babesia vogeli) with an overall prevention efficacy of 91.6%.Parasites and V… Both studies reported only minor local reactions at the application site, with no mechanical collar failures.Parasites and V…+1

Topical Fipronil-Based Products

Topical fipronil/(S)-methoprene spot-on provides flea efficacy of 67.41–100% and tick efficacy of 0.0–98.52% over 56 days in dogs without bathing, but residual efficacy is shortened by regular bathing — flea efficacy in bathed dogs ranged from 40.18–100% and tick efficacy from 0.0–98.52% over the same period.Veterinary Para… The dinotefuran/pyriproxifen/permethrin (DPP) combination maintained >90% efficacy against both adult fleas and ticks at every time point through 5 months under outdoor conditions, while fipronil/(S)-methoprene showed variable tick efficacy of 38.0–99.6%.Parasitology Re…

The combination of monthly topical fipronil 6.76%/permethrin 50.48% (Frontline Tri-Act) plus oral afoxolaner 1.9%/milbemycin oxime 0.4% (NexGard Spectra) achieved 95.8% ectoparasite-free dogs within 24 hours of first treatment, with 100% flea and tick efficacy from day 56 through day 168.Parasites and V… No adverse events, skin reactions, or hematological changes were observed over 6 months, and no new seroconversions to Anaplasma, Borrelia, Ehrlichia, or Dirofilaria were detected at study end.Parasites and V…

Would you like a breakdown of which products also provide heartworm or intestinal parasite prevention, to help narrow the choice for dogs needing a combined protocol?